Amgen

Amgen Inc. (NASDAQ: AMGN, SEHK: 4332) is an international biotechnology companyheadquartered in Thousand Oaks, California. Located in the Conejo Valley, Amgen is the world’s largest independent biotech firm. The company employs approximately 17,000 staff members. Its products include Epogen, Aranesp, Enbrel, Kineret, Neulasta, Neupogen, Sensipar / Mimpara, Nplate, and Prolia. Epogen and Neupogen (the company’s first products on the market) were the two most successful biopharmaceutical products at the time of their respective releases.

BusinessWeek ranked Amgen first on the S&P 500 for being one of the most “future-oriented” of those five hundred corporations.^[3] BusinessWeek ostensibly calculated the ratio of research and development spending, combined with capital spending, to total outlays; Amgen had the fourth highest ratio, at 506:1000.

Amgen is the largest employer in Thousand Oaks and second only to the United States Navy in terms of number of people employed in Ventura County.

With plans to expand into a new campus under construction in South San Francisco, Amgen abruptly halted construction on the plans and instead put the 365,000 square feet (33,900 m²) of new space on the sublease market.^[4]

It is a leading member of the U.S. Global Leadership Coalition, a coalition of over 400 companies and NGOs that promotes increased funding for US diplomatic and international development programs.^[5]

In 2006, Amgen began sponsoring the Tour of California, one of only three major Union Cycliste Internationale events in the United States.

Contents [hide] 1 History 2 Acquisition history 3 Products 4 See also 5 References 6 External links

[edit]History

AMGen Corporate Logo, 1983

Amgen’s corporate Gulfstream V departsFox Field, Lancaster, California

The word AMGen is a portmanteau of the company’s original name, Applied Molecular Genetics, which became the official name of the company in 1983 (three years after incorporation and coincident with itsinitial public offering). The company’s first chief executive officer, from 1980, was George B. Rathmann, followed by Gordon M. Binder in 1988, followed by Kevin W. Sharer in 2000. The company has made at least five major corporate acquisitions.

Acquisition history

• 1994 – Synergen, Inc.
• 2000 – Kinetix Pharmaceuticals, Inc.
• 2002 – Immunex Corporation^[6]
• 2004 – Tularik, Inc.
• 2006 – Abgenix, Inc.^[7]
• 2006 – Avidia, Inc.
• 2007 – Ilypsa, Inc.
• 2007 – Alantos Pharmaceuticals Holdings, Inc.

Products

As of June 7, 2010, Amgen had eleven approved drugs for sixteen conditions (conditions lists are highly generalized; see each article for more detail):

• Aranesp (darbepoetin alfa) (for anemia)
• Enbrel (Etanercept) (for various forms of arthritis)
• Epogen (Epoetin) (also known as Procrit; for anemia)
• Kepivance (Palifermin) (for oral mucositis)
• Kineret (Anakinra) (for rheumatoid arthritis)
• Neupogen (Granulocyte-Colony Stimulating Factor) (for neutropenia)
• Neulasta (PEG Granulocyte-Colony Stimulating Factor or “Pegfilgrastim”) (for neutropenia)
• Vectibix (Panitumumab) (for colon cancer)
• Sensipar (Cinacalcet) (for Secondary hyperparathyroidism, a mineral metabolism complication common in patients with kidney failure)
• Nplate (Romiplostim) (for chronic immune thrombocytopenic purpura)
• Prolia (denosumab) (for postmenopausal osteoporosis)

In other drug discovery phases (Phases I, II, III and in preclinical development), the company has twenty-three pharmacologic agents for twenty-eight conditions; nineteen of the candidates are not currently approved for any indication.