400 سؤال فى امتحان البروميترك السعودى


1- The major action of sodium chromoglycate is:-
a-mast cell stabilization b-bronchodilator
c-prostaglandins modifier d-leukotrienes modifier e-non of the above

2-The action of histamine is :
a-capillary constriction b-elevation of blood pressure
c-stimulation of gastric secretion
d-skeletal muscle paralysis e-slowing the heart rate

3-One of the following antibiotics is resistant to penicillinase :
a-penicillin V b-penicillin G
c-floxapen d-ampicillin

4- Inderal is :
a-similar in action to ergotamine
b-similar in action to tubocurarine
c-used as an antihistamine
d-pure b -adrenergic receptor blocker

5- Rifampicin is indicated for treatment of :
a-impaired fat absorption b-pulmonary emboli
c-tuberculosis d-neoplastic disorders
6- Which of the following is non selective b1 blocker ?
a-labitolol b-terazosine
c-cloridine d-captopril
7- The Latin abbreviation for ” After Meals ” is :
a- a.c. b- a.a. c- p.c. d- i.c. e- c.c.
8- The latin abbreviation for ” Four Times Daily ” is :
a- a.c. b- a.a. c- p.c. d- q.i.d. e- c.c.
9- The latin abbreviation for ” Every Night ” is :
a- a.c. b- o.n. c- p.c. d- i.c. e- c.c.

10- Erythroped A :
a-is effective against G +ve Cocci
b-is a macrolide antibiotic
c-can increase g.i.t. motility
d-could be used in pregnant women if need
e-all of the above

11- For the treatment of anaphylactic shock use :
a-salbutamol b-diphenhydramine
c-acetazolamide d-epinephrine
12- Allopurinol is used as :
a-analgesic agent b-uricosuric agent
c-antiinflamatory agent d-antipyretic agent
e-agent which increases renal tubular reabsorption
Allopurinol inhibits xanthine oxidase, reducing the conversion of
hypoxanthine and xanthine to uric acid and resulting in direct inhibition
of purine biosynthesis due to elevated oxypurine concentration (negative
feedback). Oxypurinol also inhibits xanthine oxidase. So anyway you have
dramatically decreased uric acid concentrations, decreased renal tubular
transport of uric acid, and then the side effect of increased tubular
reabsorption of calcium.
13- Which of the following is NOT betamethasone side effect ?
A-cataract b-hypoglycemia
c-skeletal muscle weakness d-sodium retention
e-lowered resistance to infections

14- A disease which is due to viral infection :
a-poliomyelitis b-rabies
c-chicken pox d-herpes
e-all of the above

15- The mechanism of action of atropine is :
a-muscarinic antagonist b-muscarinic agonist
c-nicotinic antagonist d-nicotinic agonist
e-non of the above

16- Myocardial muscle tissue property to generate electrical is :
a-inotropy b-chronotropy
c-automaticity d-contractility
e-non of the above ” Dromotropic effect”

17- The heart`s dominant pacemaker is :
a- AV node b- SA node
c-pukinje fiber d-internodal pathways
e-non of the above

18- Adenosine is used for :
a-ventricular arrythmias b-atrial bradycardia
c-supraventricular tachycardia
d-supraventricular bradycardia
e-non of the above

19- Adenosine P produces which of the following :
a-facial flushing b-dyspnea c-marked tachycardia d- a and b e- a , b and c

20- Which of the following is responcible for buffering
a-magnesium b-chloride c-bicarbonates d-potassium e-troponin

21- Respiratory acidosis is due to :
a- O2 removal b- O2 retention
c- CO2 removal d- CO2 retention
e-non of the above

22- Which of the following is NOT colloid solution ?
a-albumin 5% b-ringer`s solution
c-dextran d-beta starch
e-albumin 20%

23- The term shock signifies :
a-hyperperfusion b-hypoperfusion c-tachycardia
d-bradycardia e-non of the above

24- In treatment of shock , which of the following should be considered?
a-airway control b-IV of crystalloid solution
c-dopamine to support blood pressure
d-monitor heart rhythm e-all of the above

25- Which of the following is released by bacterial infection?(…. by bacterial cell wall during there growth)
a-endotoxin b-exotoxin c-antibiotics
d-cytotoxin e-non of the above

26- the amount of water in adult male is about:
a-25% b-60% c-80% d-10% e-17%

27- Which of the following are causes of oedema?
a- Increase hydrostatic pressure
b- Decrease oncotic pressure
c-capillary permeability
d- a and b e- a , b and
28- Patients prescribed non reversible monoamine oxidase inhibitor should be advised not to consume food containing tyramine because this combination causes:
a-postural hypotension b-hallucinations
c-anaphylactic shock d-muscle weakness and tremor e-acute adrenergic crisis including sever hypertention

29- Concerning COX 2 inhibitors , which is NOT true?
a-they have lower risk gastric adverse reactions
b-good evidence about their effectiveness
c-cardiac toxicity is a recent concern of this class
d-they usually administrated twice daily
e-combination with non selective agents give more effective action

30- In the treatment of osteoporosis which of the following is NOT true?
a-alendronate should be taken 60 min. before breakfast
b-Ca and vit. D are essential
c-hormone replacement therapy should be considered
d-outcome should be assessed with periodic bone density
e-raloxifeno is selective oestrogen modulator

31- Which of the following is the first choice in acute gout?
a-allopurinol b-indomethacin c-colchicine d-probencid e-sulfinylpyrazone

32- Which of the following is NOT a risk factor for osteoparalysis?
a-minimal exercise b-low calcium intake
c-male gender d-family history
e-minimal exposure to sunlight

33- Early symptoms of aspirin poisoning are :
a-lethergy & fatigue b-skin rash & headache
c-throbbing headache & dizziness
d-fluid retention hypotension
e-ringing in the ears & blurred vision

34- Which of the following is NOT true about infiximuab
a-IL-1 blocker
b-used for treatment of severe rheumatoid arthritis c-may increase risk of infections
d-administered as IV infusion
e-postadministration reactions include fever & chills

Inflximab is anti TNF
35- A disease modifying drugs in rheumatoid arthritis:
a-gold preparations b-hydroxychloroquine
c-methotrexate d- a and b
e- a , b and c
36- A patient who is admitted through the E.R. with an initial diagnosis arterial fibrillation
a-slow ventricular response using verapamil
b-start lidocaine infusion
c- considered anticoagulation with warfarine
d- a and c e- b and c

37- Which of the following is true about surgical prophylaxis ?
a-it is given to treat surgery associated infections
b-it is given to reduce the possibility of surgical site infection
c-should always be given regardless type of surgery
d-should be continued for 7 days after surgery
e-all are true

38- When diagnosis of diabetes to be considered :
a-WBC count with differential
b-oral glucose tolerance test c- HBA1c
d- a and b e- b and c
39- The usual daily dose of phenytoin in the range of:
a- 1-5 mg b- 15-60 mg
c- 300-600 d -should be continued for 7 days after surgery
e-all are true
40- Goals of diabetes mellitus management include :
a-reduce onset of complications
b-control symptoms of diabetes
c-near normal glycemic control and HBA1c
d- a and b e- a , b and c

41- When dosing insulin which of the following is true?
a-initial dose 0.6 u / kg / day split 2/3 a.m and 1/3 p.m
b-regular NPH ratio is 1 : 1 or 1 : 2
c-dose may need to be increased during acute illness
d- b and c e- a , b and c

42- What first line agent may be considered for an obese type 2 ?
a-glyburinid b-insulin c-metformin
d-nateglinid e-repaglinid

42- These are non aqueous pharmaceutical solutions:
a-otic soln. , mouth washes and nasal soln.
b-essences , collodions an elixirs
c-gargles , douches and irrigation soln.
d-syrups , mucillages and collodions
e-enemas , liniments and spirits
44- Which of the following drugs exhibits dose dependant pharmaceutical therapeutic doses ?
a-Na valproate b-phenytoin c-lithium
d-quinidine e-carbamazepine
45- Propranolol is often prescribed with hydralazine to
a-reduce the reflex tachycardia b-prevent the accumulation of hydralazine.
c-prevent systemic lupus ( SLE ) due to hydralazine.
d-prevent oedema e-increase absorption of hydralazine
46- The ability of a liquid to dissolve is :
a-hydrophilicity b-miscibility
c-immiscibility d-solubility equilibrium
47- Which of the following is NOT correct ?
a-glitazones are ineffective as mono therapy
b-GIT disturbance are common side effects of glycosidase inhibitors-a
c-start with small dose of oral agent and triturate up to 1-2 weeks
d-life style modification should not be enforced if an oral agent to be started
e-lisepro is rapid acting insulin to be dosed immediately before meals

48- In CHF management the following is not correct:
a-ACEIs such as lisinopril improves left ventricular function and reduces mortality
-blocker such as carvidailol may have beneficialb b- effect in selected patient
c-spironolactone should be avoided because of the great risk of hypokalemia
d-non drug therapy includes appropriate fluid and dietary sodium-restriction
e-symptomatic improvement is one of the major assessment criteria for proper therapy

49- Which of the following is NOT a primary literature
a-gournal of pharmacy practice
b-applied therapeutic & clinical use of drug
c-new England Journal of medicine

50- References to check compatibility of drugs in parentral administration:
a- MERCK Index
b-handbook on injectable drugs
c-micromedix d- a and b e- b and c

51- When a CNS depressant is prescribed , which of the following is NOT taken at the same time?
a-analgesic b-verapamil
c-aspirin d-diphenhydramine e-orange juice

52- A 4 mg dose of lorazepam administered to an adult will act as :
a-analgesic b-hypnotic c-diuretic
d-antihistaminic e-antiulcerant
53- The drug of choice to control pain during acute myocardial infarction is :
a-naloxone b-bethidine c-morphine
d-celecoxib e-naproxen

54- What is a major contraindication to the use of an OTC sympathomimetic drug
a-gastric ulcer b-uncontrolled hypotension
c-severe asthma d-rheumatoid arthritis

55-Category C in FDA for drug used in pregnancy :
a- controlled studies fail to demonstrate a risk to the fetus in the trimester and there is no evidence of risk in later trimester
b- fetal risk NOT demonstrated in animal studies but there are no controlled studies in pregnant women or animal reproduction studies have shown an adverse effect that was NOT confirmed in controlled studies in women during trimester
c-either animal study have revealed adverse effect on the fetus and there are no controlled human studies or studies in animal and women are not available
d- There is positive evidence of human fetal risk but the benefits of use in pregnant woman may be acceptable despite the risk

56- What advice would you give to a patient prescribed rifampicin?
a-take this medication with food or milk
b-avoid multivitamine preparations during treatment
c-avoid taking paracetamol during treatment
d-possible discolouration of skin is of no importance
e-this medication may cause discolouration of urine
57- Correct method of parentral administration of potassium is :
a-fast I.V. injection
b-slow I.V. injection c-I.M. injection
d-IP(intraperitoneal) injection

58- Which route of administration would provide the most rapid onset of action response to morphine ?
a-oral b-S.C. c-I.V.
d-I.M. e-rectal
59- The long term administration of thiazide diuretics requires :
a- K+ b- Na+ c- Ca++
d- CO3 e- acetate

61- When concidering drug therapy for hypertention , which is true?
a-combination of drugs always preferred
b-hydralazine is first line therapy in young hypertension
c-furosemide should be administrated before meal to improve absorption
d-beta-blokers should be avoided in asthmatic patient
e- ACEIs are recommended in pregnant women

62- Which of the following is NOT used in theophylline toxicity management :
a-symptomatic control of seizures with benzodiazepine
b-activated charcoal to enhance elimination
c- b blocker for tachycardia
d-control vomiting with metoclopramide
e-methylphenidate to reduce excessive sedation

63- Regarding the use of ACEIs :
a-associated hypokalemia could be avoided by giving K-supplement
b-effective in reducing proteinurea in diabetic patient
c-most common side effect is chronic dry cough
d-a good first line treatment for hypertensive diabetic
e-dose should be started low and triturated gradually upward in need

64- Regarding treatment of digoxin toxicity:
a-verify time of last time
b-check Mg and K levels and correct if needed c-monitor ECG
d-no antidote for digoxin e-supportive care


65- The antimalarial to be avoided in glucose-6-phosphate dehydrogenase deficiency :
a-primaquine b-quinine c-chloroguanide
68-The following is NOT characteristic of solution:
a-thermodynamically stable
b-composed of two or more component that exist in one phase
d-the solvent and solute can be separated by filtration e-solute doesn`t precipitate as time passes

69- Role of carbidopa in treatment of Parkinsonism.
a- Serotonin reuptake b- dopamine agonist
c- Decrease dopamine in peripheral vessel
d- Dopamine antagonist e- 5HT1 antagonist
70- Role of B-blockers in angina. ………….

71- When drug absorbed through GIT then go to liver and
excreted this process called
a- first pass b- drug metabolism c- drug distribution
72- All the following anti inflammatory, analgesic effect except
a-ibuprofen b- aspirin c- naprosyn d- sevredol : opioid analgesic
73- which of the following need filtration before IV infusion
a- mannitol b- dextrose 5% c- insulin
d- Suspension e- emulsion
74-azaleic acid used in
a-acne b- psoriasis c- myocardial infarction
75- which hormone are secreted from posterior pituitary gland
a- oxytocin b- growth hormone c-adrenocorticosteroid hormone
76- to increase duration of lidocaine in anasethia
a- propranolol b- succinyl choline c- epinephrine
d- Atropine e- ……………..
77- Drug absorption depend on
a- age b- sex c- dosage form
d- Drug state e- A and B
78-monitoring for dose in elderly patient:
a- excretion in kidney decrease b- decrease in liver enzymes function
c- reabsorption is high d- metabolism is high e- A ,b
79-which of the following cause metallic taste
a- captopril b- cimetidine c- metoformin d-………………

80- which of the following are characteristic for Erythroped
a- not effective against G +ve cocci
b- not macrolide antibiotic
c- can increase GIT motility
d-can not used in pregnant women if needed
e- none of the above
81- which of the following are characteristic for Erythrosine:
a-not effective against G+ve cocci
b- has amino glycoside antibiotic
c-decrease GIT motility
d-should not be used in pregnant woman if need
e-should be used in pregnant woman if need
82-the optimal size for ophthalmic drops:- < 10μg
83- Amphetamine is used in: defect of awareness in the brain of children.
84-if packaged are written for expiry November 2006 it mean that can be used till
a- 1 November b- 31 November
85-The mechanism of action of Buspirone through a-5HT agonist b-GABA agonist
c-dopaminergic agonist d-dopaminergic antagonist
86- Nitroglycerine introduces: coronary vasodilatation.
87- Omeprazole used to: decrease gastric acid secretion.
88- which of the following has aldosterone antagonist effect
a- amiloride b- furosemide c- spironolactone d- hydrochlorothiazide

89-which of the following change color of the urine to red nitrofurantoin , rifampicin
90- if patient take Gentamicin for a time which of the following need monitoring test
a- serum creatinine level b- liver enz. test
c- hemoglobin test d-…………………. 91-which of the following is antiarrythmic class Ιa:-
a- lidocaine b- propranolol c- amiodarone d-Quinidine
92- Class ΙΙ antiarrythmic drugs produce its action through:-
a- decrease rate of phase 0 depolarization b- increase phase 3 repolarization
c- suppress phase 4 depolarization d- adrenergic receptor blocking
e- shorten action potential
93- antiarrythmic drug class Ιb produce its action through:-
a- decrease rate of phase 0 depolarization b- increase phase 3 repolarization
c- decrease phase 4 depolarization d- adrenergic receptor blocking
e- shorten phase 3 repolarization

94- Chiral molecule mean:-
a-dipole moment b- solubility c- chelating prep. d-optical activity.
95-lovastatin produce action through:- HMG-co reductase inhibitor.
96- lisopril , zinopril or zestril is found in :-
a-captopril b- fosinopril c- ramipril d-lisinopri

97- ″ am″ is abbreviation for at morning.

98- ophthalmic prescription are written through following ( gtt tod Bid ) this mean:-
a- give one drop to right eye twice daily
b- give one drop to left eye twice daily
c- shake well and then give one drop to left eye twice daily
d- shake well and then give one drop to right eye twice daily.
99-tegretol is used in ttt of:- status epileptic, seizures.
100- Streptokinase is used in ttt of:- pulmonary emboli.
101-all the following are antifungal except:-
a- Nystatin b- Amphotericin c- Ketoconazole d- Gamciclovir.
102- ceftazidime is:-
a- first generation cephalosporin b- second generation cephalosporin
c- third generation cephalosporin d- fourth generation cephalosporin
103- Bambuterol is used in:- treatment of asthma.
104- Drug used in ttt of traveler diarrhea:-
a-ampicillin b- amoxicillin c- co-trimoxazole d- ciprofloxacin
105- Which organism are the cause of traveler diarrhea:- E-coli.
106-diazepam used in:- anxiety.
107-solid to be reduced in size before dissolving called:- disintegration.

108-Benzodiazepine mechanism through:- binding δ subunit of GABA-A receptor.
109-Vinca alkaloids produce anticancer drugs :- vincristine , vinblastine . vindesine.
110- warfarin monitoring therapy by:-
a- INR b- platelet count c- APTT d- lipid profile
international normalized ratio ( determine the blood tendency to clot ) normal range 0.8 – 1.2 PT
( prothrombin time)
111-in ovulation phase which hormone is predominant :-
a-FSH b-LH c- progesterone d- progesterone and LH
112-vecuronium is used as :- skeletal muscle relaxant.
113-most common process for sterilization:-
a- filtration b- dry heat c- moist heat
114-which of the following need serum level monitoring with Quinidine:-
a-Digoxin b- albutrol c-ampicillin d-Diazoxide
115- side effect of epinephrine is:-
a- nausea , vomiting b- headache , constipation
c- hypoglycemic effect d- ischemic damage e- skin rash
116-drug used for ttt of migraine and HTN:-
a-clonidine b- minoxidil c- propranolol d- hydralazin
117- can’t be used as monotherapy in mild HTN:-
a- hydralazine b- losartan c- pindolol
d- atenolol e- hydrochlorothiazide
118- which of the following has catharitic side effect:-
a- aluminum silicate b- magnesium sulphate c- calcium sulphate
119-normal water can be used in:-
a- parentral prep. b-ophthalmic prep.
c- oral susp. d-external prep.
120- Ecothiophate mechanism through:-
a-binding to muscarinic receptor b- cholinergic antagonist
c- make complex with acetylcholinesterase and inhibit its action
121-tetracaine is used as:-
a-opoid pain b- vitD metabolite
c- spinal anesthesia d- neuromuscular blocker
122-half life for first order kinetic:-
a- k b-1/k c- 2k d- 0.693k
123-adsorption are affected by the following except:-
a- physical Rx b- chemical Rx c- irreversible
d- reversible e – B,C
124- Charcoal produce its action through:-
a- adsorption
125- Digoxin used in ttt of CHF as has:- + VE inotropic effect

126- PPM mean:- part per million OR million part

127-all are causes of 2ry HTN except:-
a- phyochromocytoma b- cholinergic agent c- sod. intake d- …………..

128-pt CHF take digoxin and hydrochlorothiazide with ray arthritis which of
a-cortizone b-hydrocortisone c-fluticazone d-prednisolone
129-if a drug has the same active ingredient like other drug but not contain the same inactive ingredient this mean :-
a- Bioequivalent b-pharmaceutical equivalent c- pharmaceutical alternative d- A,B
130- conc. of adrug is 7.5 mg in teaspoonful
what will be conc. in 150 ml:-
7.5 mg________ 5ml
x? mg________ 150 ml
ْْْْْx mg=7.5×150/5 =225 mg
132-which of the following is not colloid
A-kerbs solution b- albumin 2% c- Dextran
d- Beta starch e- albumin 20%
133-sildenafil is found in Viagra.
134-Alteblase is used:- fibrinolytic (thrombolytic)
135- salbutamol is used as:- bronchodilator
136-podocodeine is used in dry cough
137-which of the following not used in emergency HTN:-
a- furosemide b- pindolol c- labetolol d-………….
138-Doxorubicin side effect :-
a- cardiac toxicity b- nephrotoxicity
c- postural hypotension d- arrhythmia
139- which of the following not used in ttt of asthma:-
a- B2 agonist b-B2 antagonist
140- Which of the following is alkylating agent and anticancer
a-vinblastine b- cisplatin
c- Cyclophosphamide d- vicristine
141- Very small molecule(1 part ) soluble in 10,000 part of water
a- fairly soluble b- slightly soluble
C-immiscible d- miscible e- insoluble
142-benzoil not soluble in H2O but soluble in benzene in 25◦ c
a- polar b- non polar c-soluble
d- insoluble e- slightly polar
143- one of the following is member of phenothiazines group prochlorperazine antipsychotic
144-primidone is prodrug for ( antiepileptic drug ).
145- Daily recommended dose for folic acid 400-500 μg
146- Daily recommended dose for vit. C in male :-
a-30mg/day b-50 mg/day c-90mg/day d-200 mg/day e- 400 mg/day
147- Daily recommended dose for vit. C in female :- a-30mg/day b-50 mg/day c-90mg/day d-200 mg/day e- 400 mg/day `
148- max. daily dose for paracetamol is ( 4000 mg )
149- Ergot alkaloids is used as ttt migraine
150- Buffering agent used in ophthalmic drops to:- decrease irritation to eye and increase stability
151-picosulphate is used as laxative
152- Digoxin toxicity increase with:-
a- renal failure b- hepatic pt
c- Asthmatic pt
153- All the following are side effect of oral contraceptive except:-
a-hypertension b-weight gain
c- Hyperglycemia d- dizziness e- constipation
154-which of the following narcotics not used today:-
a- morphine b- heroin
c- nicotine d- codeine
155- drug stored in the body in:-
a- fat b- muscle c- connective tissue d- lipid e- protein
156-which of the following dosage form are famous:-
a- solution, gel, oint. b- oint , gel , solution
c- oint, solution , gel e- solution , oint , gel
157- in case of hepatic or renal failure which muscle relaxant is recommended :-
158- Heparin can be monitored through :-
a- APTT b- INR c-PT d-IM
A Partial Thromboblastine Time ( time taken by plasma to clot)
159-Enixoparin is administrated:-
a- IM b- IV
c- S.C. d- IV infusion
160- if drug protein binding increased or decreased:-
a- half life ↑ b- half life ↓
c- side effect ↑ d- action ↑ e- a,b
161-3rd generation cephalosporin has:-
a- G+ only b- G-ve only c- G+ve , G-ve
162-solubility enhanced through :-
a- reduce particle size b- increase surface area
c- increase particle size d- decrease surface area
e- A&B
163- determination analysis of solution depend on
a-nature of solute b- type of solution
c-analyzer d- a.b
164-when use liquid or oint. to dissolve the solid it is called :- levigation
165- phenytoin act on :- GABA receptor 166- NSAIDs produce action through:-
decrease prostaglandin synthesis
167- which of the following not characteristic of theophylline:-
a- relaxation to brochial smooth muscle b- increase cardiac contractility, CO
c- nausea , abdominal disturbance
e- convulsion d- sedation
168- what is drug of choice in ttt of bronchospasm/asthma:-
a-salbutamol (albutrol ) b-theophylline c-propranolol
d-esmolol e- quinidine
169- which of the following cause depression :-
a- ampicillin b- reserpine

170- PREVOC is trade name used as:-(ticlopdine)
a- anticoagulant b- antiplatellet c- antibiotic d- anti asthmatic
171- pound = 0.453 kg
172- sustained release dosage form is used to
a-increase half life b- drug have low therapeutic index
c- ………………………..
173- drug after metabolized in liver it will become:-
a-polar b- non polar
c- lipophilic d- insoluble
174- loading dose definition
175- in phase 1 in muscle contraction occur:-
a-depolarization for k in
b- repolarization to ca out
176- half life of drug is 7 days HOW can taken:-
a- every day b- twice daily
c- twice weekly d- every week

177- diltiazim classified as : . Ca channel blocker

178-B carotine is precursop of : a-retinol b- thiamine c-riboflavin d- pyridoxine e- calcefirol
179- electrical property which produce impulses called :
a-conduction b-automaticity c-velocity d- excitability

180- infusion of hypotonic solution in blood cause :
a) shriniking of blood cell
b) hemolysis
c) hyperglycemia
d) hypoglycemia
e) b + d

181- infusion of hypertonic solution in blood cause :
a) shriniking of blood cell
b) hemolysis
c) hyperglycemia
d) hypoglycemia
e) b + d
184- denaturation will happened in body for which compounds?
a-penicillin b- proteins c- lipid d-carbohydrate e-…………
185- major metabolism proccess in GIT is:-
a-hydrolysis b- acetylation c- oxidation d-conjucation
186- dosage form of nitroglycren when used in malignant hypertension ?
a-IV b-IM c- S.C d- infusion e- transdermal
187- drug induced lupus like syndrom is associated with antihypertinsive ?
a-minixidil b- hydralazine c- dioxide d-nitroprusside Na e- acebutol

188- hypothirodism cause :- a-weight gain b- hypoglycemia c-low body temp d-………..

189- ACE I mechanism of action as antihypertension ???
– inhibition of converting angiotensin I to angiotensin II

190- About definition of first pass effect , it increase with:-
a- increase rate of absorption b- increase biotransformation c- increase pka
d- A&B
191- metal used in rheumatoid arthiritis : gold
192- low density lipoprotein(LDL) act as :
a-carrier cholesterol in plasma b- transport fatty acid c- good lipoprotien.

193- true solutions another name is:-
a- homogenous b- heterogenous c-emultion d- suspension

194-about ophthalmic preparation as single dose which is false:-
a-sterile b- purified c-should cotain preservative d-………..

195-most of drugs are :
a-Weak electrolyte
b-Non electrlolyte
c-Non ionic
d-Strong electrolyte
e-B+ C
197- antipseudomonas drug :
a-metronidazole b-nystatin c- primaquine d-vancomycin
198-digoxin differ from digitoxin :
a-Half life
b-Excreted hepatically
d-Excreted unchanged in urine
199- In digoxin induced arrythmia , what is not recommonded?
a-stop digixin administration
b-phenytoin administration
c-give lidocaine
d-give digoxin immune fab
e-electrical cardio

200- which is not asthma properties :
c-Increase mucous secretion
d-Chest pain

201- hormone not excreted from adrenal cortex :
a-Growth hormone
b-Primary product
c-mineral corticoids (eg, aldosterone)
d-glucocorticoids (eg, cortisolndrosterone)
e-weak androgens (eg, dehydroepiandrosterone)
203- all of the following are side effects of methotrixate except :
a-Bone marrow depression
c-Nausea and vomiting
e-Drive sex gland

204- mechanism of action of antipsychotic drug :
Dopamine receptor inactivation
205- ACE inhibitors are contraindicated in :
bilateral renal artery stenosi
206- about cardioglycosidic effect :
a–ve inotropic
b-+ve inotropic

207-all factors affect on distribution of drug except :
a-Tissue solubility
b-Protein binding
c-Molecular weight of drug
d-Type enzyme response of metabolism


208-all factors affect on renal clearance except :
d-Disease state
209- ointment used for :
a-Carrier of drug
d-Increase absorption
e-Increase distribution
210- in hypodynamic shock treatment we used :-
a- dopamine
b- nicotine
c- aspirin
211-acyclovir used to :
Herbs simplex
212- lady take chronic warfarin , which is not true
a- avoid aspirin containing prepration
b-avoid doubling dose from herself
c-balanced food with green leaves to avoid thrombosis
d-if she pregnant, monitor INR to avoid DVT
e-take care about nasal bleeding

213- which of following is least sedative action ?

214- which drug has spasmolytic action?

215-desmopressine used in :-
nocturnal enuresis &diabetes insipidus

216- pentoxiphyllin used for : a-peripheral vasodilator
c-Cough suppressant Indications
Pentofyllin is indicated in diseases, causing disorders in the peripheral perfusion, and in diabetes, atherosclerotic and inflammatory disorders, including shank ulcers; gangrene; diabetic angiopathy; intermittent claudication; Raynaud’s disease. In acute disorders of the brain perfusion, including ischemic stroke and resultant conditions. Acute disorders of the retinal blood supply.

218- normal water used for :
a-Eye preparption
b-Parentral preparation
e-External preparation

219- ceftazidime :
3rd generation

220-about amino glycoside , which is not true ?
a-Has gram –ve activity
b-Less toxicity
c-Narrow therapeutic
d-Compatible with other drug
e-Usually IV , IM

221- about nor epinephrine not true :-
a-increaser B.P
c-used in cardiogenic shock
d-effective orally

a-Zero order
b-1st order
c-2nd order
d-Mixed order
e-A + B

223- Which of the following is NOT predinsolone side effect ?
a-cataract b-hypoglycemia
c-skeletal muscle weakness d-sodium retention
e-lowered resistance to infections

224- When concidering drug therapy for hypertention , which is true?
a-combination of drugs always preferred
b-hydralazine is first line therapy in young hypertension
c-furosemide should be administrated before meal to improve absorption
d-b-blokers should be avoided in asthmatic patient
e- ACEIs are recommended in pregnant women

225-solutions are better than solid dosage form coz:
a-Accurate dose
b-Easy to handle
c-More stable
d-Faster action
e-B + C

226- One of following NOT used to cover bitter taste:-
a-Film coat
b-Enteric coat
c-Grinding of tablet

227-which of following tricyclic antidepressant is tertiary amine?

228- antihypertensive used in pregnancy ?
Alpha Methyldopa

229-drug used for peptic ulcer ?( Losec)

230- drug infusion rate is 2mg\kg\hr , infused for 12 hours , for 70kg patient. what is total dose?
(2x70x12)=1680 mg

231-( GMP) mean:- Good Manufacturing Practice
a-Good Manufacturing Protocol
b-Good Manu factor Product
c-General Manufacturing Protocol
d-General Manufacturing Product

233- according to steril method which of the following is false about filtteration:-
عليك أن تختار able to filtter viscous substance
234- when you know the preservative used with anti biotic is not suitable you make:-
a- use another one is suitable
b- add another to increase it is activity
c- use tow or more preservative may increase the activity and may become suitable
d- a+c

235- deltiazem & nifedipine &flocdipine act as
– block Ca to intracellular & increase metabolism from storage site

236- All of this affect rate of absorption except:-
a- chemical stability b- PH
c-protein binding d- A&B e- B&C

237-Aiteplase &streptokinase used in:-
( Pulmonary emboli )
238-Cholystyramin resin act by :- anion exchange
239-The conc. Of ionized & unionized calculated by (Henderson hasselbachk equation)

240- Light sensitive drug should be storage in:-
a-Colorless glass b-Colorless plastic c-Amber glass d-Amber plastic e-Light resistant container

241-Electromagnetic rays :- gamma rays, x-rays.

242-Cyclophosphamide (side effects) Appetite loss; absence of menstrual periods; color change in skin; diarrhea; general unwell feeling; hair loss; nausea; skin rash; stomach discomfort or pain; texture change in nails; vomiting; weakness.

243-Isoproterenol( Isoprenaline )
adrenergic agonist medication.

244-Coal tar uses in (psoriasis).& dandruf
245-The most common reaction catalysed by cytochrome P450 is a monooxygenase

246-The most common phase I reaction is oxidation

247-Which Of The Following NOT Used In Peptic Ulcer :-
a-Tetracycline b- Itraconazole
c-Metronidazole d-bismuth subsalicylate

248-Which Of The Following act as alpha 1 blocker :-
a- hydrazyline b-terazocine
c-propranolol d-captopril
e- clonidine

249-comparison between sterile water &water for injection:-
a- pyrogen free b-free from sod. Chloride
c- Isotonic d-free from bacteria
e- A&C

250- Qunidine has similar action to :-
a-procainamide b- lidocaine
c-propranolol d- hydralzyine

251- Which of the following drug has side effect lupus like syndrome :
a- lidocaine b-minoxdile
c- procainamide d-hydrochlorothiazide

252- Over dose of digoxine we use:-(anti dote FAB Fragment ).

253- Ampicilline has similar action of:-
a- tetracycline b-cephalexin
c-cloramphinicol d-amikacine

254- Cephalosporin act as:-
a-Inhibitors of cell membrane function
b-inhibitors nucleic acid synthesis
c-Inhibitors of protein synthesis
d-Inhibitors of cell wall synthesis
e-Inhibitors of metabolism

255- Antibiotic used as anti pseudomonas aeruginosa:-
a- Meropenem b- Bacitracin
c- Amoxicillin d- penicillin V

256- Antipseudomonal Antibiotic :- (piperacillin,carbencillin,ticarcillin )

257-Auxliar of label are written on box contain CO-TRIMETHOXAZOLE all is true except:-
a-shake the bottle before use
c-freezing of drug
d-keep out of reach of children

258-Ipratropium bromide :-(Anti muscarinic bronchodilator )

259-keep in cool place means :-
a-in refrigerator
b-in freezing
c-at 10-20 c*

263-Increase plasma HDL Level :-
(Reduce Risk of Atherosclerosis )

264-Waraferin act as:- (inhibited blood clot ) anticoagulant
265-cyclophosphamide side effect is:-
a-blared vision,……………
b-vomiting .alopecia
c-bone marrow depression

266-Action of alpha 1 receptor:-………………….

267-which of the drug used in open angel glaucoma:-
(pilocarpine )

268-All (ACEIs) are prodrug except:- CAPTOPRIL (prototype)

269-Opthalmic prep. Proffered to be taken:-
a-solu. > susp. > oint.
b-solu. > oint > susp.
c-susp. > solu. >oint
d-any dosage form can be used

270-digoxin toxicity precipitated by : – (Hypokalemia )

271-which of the following drug has anti inflammatory effect :- (Ibuprofen )
272-Digitoxine effect in electro cardio chart (ECG):-
a-prolong P.R b-shorten P.R

273-Digitoxine toxicity effect in electro cardio chart (ECG):-
a-prolong P.R b-shorten P.R
c- T. shaped d-prolong B.R
274-Relative bioequivalent compared between std. drug &test drug acc. To :-
AUC (Area Under the Carve )

275-Cephalaexine is :-first generation cephalosporin.

276-After the myocardial infraction we use :-
Anti platelet (aspirin)


278-Omeprazol used for :- peptic ulcer

279-Alph 2 Agonist :-
Decrease blood pressure

280-The equation that determine the acid & base degree is:- (BRONESTED EQUATION )


282-mechanism of action of Buspirone on:-
Serotonin (5HT2a) receptor

283-All these cases not cure with thiazides except:-
a-hypernatrimia b-Hyperglycemia
c-Hypokalaemia d-Hyeruriceamia

284-Which of the following drug of choice for Myxodema:-
(Hypothyroidism ) :-Thyroxin sod.

285-Vit. A daily dose is 30,000-50,000 IU for the correction of the deficiency &for therapy from 100,000-200,000 IU/day.

286- All these cases not cure with thiazides except:-
a-hypercalcemia b-Hypoglycemia
c-Hypokalaemia d-Hyeruriceamia

287-Zidovudine is used for HIV.

288-Bisacodyl used as :- Laxative

289-POM mean:- prescription only medicine


290-The con. Of the drug on exp. Date is :-
From 90-110%
291-Surfactant not used orally :-
Sod. Lauryl Sulphate

292-The drug transfer through the cell membrane by :-
a-Aqueous diffusion b-Osmotic pressure
c-Lipid dissolve d-Passive diffusion
e-NON of the above

293- Calcipotriol is indicated for :- PSORIASIS

294-which of the following make water retention:-

295-Nitroglycerin is :- (Vasodilatation of coronary artery).

296-Anti psychotic act as :- (Dopaminergic Antagonist )

297- Vit, K is antagonist of :- WARAFARINE

298-protamine sulphate is anti dote of:- HEPARINE

299-Prmethazine used as :-
Anti histaminic (pruritus , cough ,anti emetic)

300- Which Of The Following act as alpha 1 blocker :-


302-ESMOLO is:-
Short acting B- blocker used in emergency in
Acute arrhythmia as IV administration .

303-which of the following has not effect on drug response:-
a-nutrition b-genetic
c-mental status d-age e-disease

304-cyclizine used in :-
a-nausea &vomiting b-antibiotic
c-bronchodilator d-antihistaminic

306-which of the following is not side effect of propantheline:-
a-blurred vision b-dry mouth
c-constipation d-bronchospasm
e-urinary retention

307-propencid increase the con. Of penicillin through :-
a-increase renal tubular reabsorption
b-decrease renal excretion
c-decrease hepatic metabolism

308-one of the following not toxic effect of methyl dopa:-
a-sedation b-drug fever
c-gangrene d-anemia

309-patient take cisplatin should be taken with :-
Granisetron (anti emetic )

310-purified water can not used in:-
a-ophthalmic preparation
b-IV solution
c-oral preparation
d-oral suspension


311-ascobic acid is 🙁 vit. C )

312-Mecanism of action of Tri cyclic antidepressant:-
Serotonin & NE Reuptake Inhibitor
313-Isopretrenol is :-
a-alpha &beta agonist b-alpha blocker
c- alpha agonist d-beta agonist
e-beta blocker

314-Active immunity can be conferred by :-
a-anti toxin b-anti sera
c-vaccine d-immuno bodies

315-Mechanism of action of echothiophate:-
( Form stable complex which cholinesterase enzyme )
(Indirect-Acting Cholinergic Agonists )
(Anticholinesterases <irreversible> )

316- The latin abbreviation for<state>:- (Immediately )

317- Volume of blood /mint cleared through kidney called:-
a-total body clerance b-renal clerance
c-hepatic clerance d-……………….

318-ventamix is :- (bronchodilator)

319-Diltiazem not used in :-
a-heart falier b-Angina pectories
c-Hypertention (HTN) d-SA node block
e- Headach

320-Drug used in Diarrhea &constipation :-
a-polycarbophil b-pictin
c-senna d-…a&b………

321-Alpha blocker has side effect :- (postural Hypotention )

322-the dose of cefixime :-
a-400mg b-800mg
c-1200mg d-1500mg
323-the dose of asprin as antiplatelet:-
a-80mg b-120mg ““““
c-250mg d-500mg
324-Alpha calcidiol can not used with patient:-
a-liver dysfunction b-renal dysfunction

325-co-trimethoxazol precentage of trimethoprim to sulphmethoxazol is :
a-1:2 b-1:3
c-1:5 d-1:10

326-diazepam over dose ttt with:- (flumanzenil)

327-Thephylline side effect is :
a-skin rash b-insomnia

328-Dipivefrine is:-
a-Anti HTN b-chelating agent

329- Which of the following Not occur in digitalis toxicity:- a)hypokalemia b)hypomagnesia c)hypocalcemia d)hypothyroidism e)impaired kidney function.

330-class IV anti arrhythmia is :- (verapamil)

331-Patient who is allergic to penicillins use:-
a) claforan b)erythromycin c)cefotetan d)augmentin e)cephalexin.

332-Tetracaine used for:-
a) Spinal anesthesia b) opioid analgesic c) neuromuscular blocking agent d) vit d metabolite c) in treatment of Parkinsonism.

333- Sterility through .22 m filter, do not remove:-
A)bacteria b)virus c)fungi d) a+c e)b+c
334-Not used clinically:-
a) heroin b)morphine c)codeine d)oxycodiene hydro morphine.

335- Which increase the action of morphine:-
a ) vit k b)carbazepine c)amidarone d)contraceptive e)none of the above.

337-side effect of class 2 antiarrythmic:- ( bronchospasm )

338- In (C.H.F.) congestive heart failure we use digoxin to:- a) incr.myocardiac contraction b) increase myocardium excitability c) dec.myocardiac contraction d)……………………………………………

339-The least sedating:-
a) Diazepam b) chlorodiazepoxide e) probamate f) oxazepam g) buspirone

340-drug not decreases LDL:-
a)simvastatin b) clobifibrate c) nicotinamide d)propecol


342-Promethasine is used for:- (antihistamic)

343-Which of the following Not used in diagnosis of acute (M.I. ) myocardial infraction:-
a)albumin b)signs and symptoms c)troponin. d) scurvy e) a& d.

344-Cushing syndrome caused by taking:-
1- Glucocorticoid drugs & 2-tumor secret high cortisol level……

345-Q.d.s. means to be taken 4 times daily.
346-Vit A avoided in:-
a) Rickets b) blindness c) pregnancy d) scurvy e) a &d

347-Which not effect of theophilline:- a)preiphral vasoconistriction b)cardiac stimulation c)dieresis d)relax of stomach muscles e)stimulation of C.N.S.

348-Not expected with inhaled smoke of cannabis:-
a)increase pulse rate b)anorexia c)preceptal changes d)vascular changes of eye.

349-Percentage of water acc. To body weight is…..60%
350-Na picosulfate is used for …laxative…..

351-Dopamine is used in cardiac shock as:-
a) increase lung performance b) decrease C.O.P. c) Don’t induce preiphral vasoconistriction d) dec.force of contraction e) selective dilate renal & mesenteric

352- Verapamil can increase effect of (theophylline & carbamazepne&digoxin….) as a liver enzyme inhibitor

353-Used in treatment of parkinsonism:-=
a)amphetamine b)dopamine c)nicotine d)albuterol

354-Aspartame is used as………sweetener…

355- Hormone replacement therapy in all postmenopausal women :-
a)true b)false

356-Properties of catecholamine:-
a)rapid metabolism by ACHE. b)slow metabolism by ache c)slow COMT d)rapid metabolism by COMT and MAO.
357-antihypertensive act as alpha 1 blocker in artery & vein:-
a)hydralazine b) minoxidil c)terazocin d)…… ……

358-bile acid sequestrantsيطلع عليها
359-ACEIs & ARBs r contra indicated in :- renal artery stenosis patient
360-cycloserine used in T.B for how long?????
361- natural water can be used in :- external preparation

362-ideal volume of eye solution:-
a)500micro b)50-250 micro c)10-50 micro d)<10 micro

363-dipivefrene is:- epinephrine analoug used in glaucoma

364-idoxrubicin is:- antiviral for herpes simplex

365-when pharmacy owner give direction to employee in his pharmacy to monitor policies& regulation it is : -a)danocratic b) democratic c) participation d)consultative


A-tachycardia b-bradycardia

368-propranolol is:- (none selective b-blocker)
369-which of the following drug cause tachycardia:-
a-propranolol b-atenolo
C-hydralazin d-……………

370-enkefaline as peptide used in :-
a-electrical conduction as neuron transmitter
b-similar in action to morphine
373-pentoxifylline use as :-
a-peripheral vasoconstriction
b-dry cough

374-the main site of execration of the drug in the body is:-
A-kidney b-liver

375- clofibrate act as :-
1-decreas HDL
2-deacreas lipoprotein lipase
3-synthesis of cholesterol
4-decreas lipoprotein

376-water used for reconstitution of large dose of parentral is:-
a-sterile water for for injection
b- water for injection
b-distal water

377-all of the following side effect of hydrocortisone except:-
a-Na retention
b- glucose intolerance
d- osteoporosis

378-reserpine side effect:
a-parkinsonism b-depression

379- pH use to :
a-determine acidity
b- increase with basic
c-for POH

380- Enzyme CYT P450 discovered by :-

382- Which of the following drugs is a systemic amoebicide?
a-Diloxamide furoate
d-Sodium Stibogluconate

383-Which of following drugs is the drug of choice for the treatment of all forms of Schistosomiasis?

384-Which of the following drugs can be used for the treatment of influenza A infection ?

385-Which of the following drugs is used in the treatment of Leishmaniasis?
c-Sodium Stibogluconate
386-All of the following preparations contain alcohol except:-
a-Syrup simplex
b-Aromatic ammonia spirit USP
c-Terpin hydrate elixir USP
d-Belladona tincture B.P
387-Wich of the following solutions is used as an astringent?
a-Strong iodine soluotin USP
b-Aluminium acetate topical solution USP
c-Acetic acid NF
d-Benzalkonium chloride solution NF
جمعية الصيادلة المصريين بالرياض

388-anextrapyramidal adverse effects is caused by the blocking of:-
a-Serotonin receptors in the brain
b-Acetylcholine receptors in the brain
c-Dopamine receptors in the brain
d-Dopamine receptors outside the brain
389-A rare side effect of some anticonvulsants is Stevens-Johnson syndrome.this is a severe:-
a-Skin reaction
b-Bone marrow toxicity
c-Renal failure
d-CNS suppression
390-Which of the following are side effects of phenytoin treatment?
c-Gingival hyperplasia
d-a,b,and c
391-all factors affect on distribution of drug except :-
a-partition co-efficient
b- Rate of blood flow to tissue
c- PH
d- A&B
e- B&C

392-Which of the following is NOT betamethasone side effect ?
b-skeletal muscle weakness
c-sodium retention
d-lowered resistance to infections

393-Which of the following are causes of oedema?
a-increase hydrostatic pressure
b-decrease oncotic pressure
c-increase capillary permeability
d-all of the above

394-All These are side effects of Chloramphenicol except:-
a- Irreversible a plastic anemia
b- optic neuritis
c- peripheral neuritis
d- iron deficiency anemia

395-Ticlopidine is used for :-
a- Anticoagulant
b- Antibiotic
c- anticholinergic
d- Antiplatelets

396-All these drugs are fibrinolytic except :-
a- Dipyridamole
b- Steptokinase
c- urikinase
397-All These drugs cause anti-metabolic effect except :-
a- Methotrexate
b- Flurouracil
C- Cytabrin
e- Cyclophosphamide

398-All These drugs can be used for Parkinsonism except :
a- Selgitine HCL
b- Carbidopa
c- Pergolide
d- Nedocromil Sod.

399-Cardiac arrest could be managed by the following except :-
a- Ephedrine
b- LIdocaine
c- Propranolol
d- Normal saline

400-Insulin which can be given I.V. is :-
a- Regular type
b- 30/70 type
c- NPH type
d- Non of the above
401-All These drugs are anti-bacterial except :-
a- Zalcitabine
b- Lomefloxacin
c- Cefprazone
d- Non of the above

402-All These are natural Estrogens except :-
a- Mestronol
b- Oestrone
c- Oestriol
d- Oestradiol

403-Which one of the following has vasodilator effect :-
a- Nicotine
b- Cholestyramin
c- urikinase
d- Vit. A

404-One of the following is not from Quinolone group :-
a- Nalidixic acid
b- Quinine
c- Eoxacin
d- Norfloxacin
405-One of the following is not for Epilepsy :-
a- Clorizepam
b- Phenytoin
c- Primidone
d- Imipramine

406-Sumatriptan is used for :-
a- Hypertension
b- Treatment of migraine
c- Angina Pectoris
d- Control of Epilepsy

407-All of the following for prophylaxis of asthma except :-
a- Ketotifen
b- Nedocromil Sod.
c- Sod. Cromoglycate
d- Salbutamol
408-All of the following is NSAH [ non sedating antihistamine ] except :-
a- Loratidine
b- Cetrizine
c- Astemizol
d- Azotodin

409-All of the following are controlled drugs except :
a- Rivotril
b- Epanutin
c- Sresolid
d- Diazepam
410-Which one of the symptoms does not occur with morphine :
a- Diarrhea
b- Respiratory depression
c- Constipation
d- Vomiting
411-Which one of these drugs is not used for acute pain :-
a- Naproxen
b- Colchicine
c- Codeine
d- Prednisolone
412-Hepatitis Vaccine dose is :
a- Once / year
b- Twice / Year
c- Three times / Year
d-None of the above
413-One of the following is given once daily:-
a- Amorphous Insulin
b- Protamine Zinc Insulin
c- Neutral insulin
d- Regular Insulin
414-Dobutamine is given I.V. because :-
a- It is not stable in the gastric PH
b- It is needed in large quantities in case of oral route
c- It is eliminated very quickly
d- None of the above
415-Amiloride as trimetren causes :-
a- CNS disturbances
b- Hyperkalamia
c- Hypokalamia
d- Not affect K [ Potassium ]

416-Cefaclor is :
a- Ist, Generation Cephalosporin
b- 2nd, generation Cephalosporin
c- 3rd, generation Cephalosporin
d- None of the above
417-Which Aminoglycoside antibiotic can be taken orally ?
a- Gentamycin
b- Neomycin
c- Amikacin
d- Tobramycin